Notice: Function _load_textdomain_just_in_time was called incorrectly. Translation loading for the wordpress-seo domain was triggered too early. This is usually an indicator for some code in the plugin or theme running too early. Translations should be loaded at the init action or later. Please see Debugging in WordPress for more information. (This message was added in version 6.7.0.) in /var/www/html/wp-includes/functions.php on line 6260 DHEA - Nutraceuticals World

What are you searching for?

Sign in
Research

DHEA

Author Image

By: Sean Moloughney

Editor, Nutraceuticals World

Indication: Depression

Source: Arch Gen Psychiatry, February, 2005;62(2):154-62.

Research: To evaluate the efficacy of DHEA as a monotherapy treatment for midlife-onset depression, a double-blind, randomized, placebo-controlled, crossover treatment study was performed from January 4, 1996, through August 31, 2002, on 43 men and 43 women between the ages of 45 and 65. The subjects had either midlife-onset major or minor depression. The study was carried out at The National Institute of Mental Health Midlife Outpatient Clinic in the National Institutes of Health Clinical Center, Bethesda, MD. Subjects underwent six weeks of DHEA therapy, including 90 mg per day for 3 weeks and 450 mg per day for 3 weeks, and 6 weeks of placebo.

Results: Six weeks of DHEA administration was associated with a significant improvement in the 17-Item Hamilton Depression Rating Scale (HAMD) and the Center for Epidemiologic Studies Depression Scale ratings compared with both baseline and six weeks of placebo treatment. A 50% or greater reduction in baseline HAMD scores was observed in 23 subjects after DHEA and in 13 subjects after placebo treatments. Six weeks of DHEA treatment also was associated with significant improvements in Derogatis Interview for Sexual Functioning scores relative to baseline and placebo conditions. These results led researchers to believe in DHEA as an effective treatment for midlife-onset major and minor depression.

Add us as a preferred source on Google

Get the latest Nutraceuticals World news, insights and analysis in your Google Search and AI experiences.

Add Nutraceuticals World as a preferred source on Google (opens in a new tab)

Keep Up With Our Content. Subscribe To Nutraceuticals World Newsletters